Solvent in Solute System for the Synthesis of Highly Substituted Pyridine by Using Choline Hydroxide and Water. (26th May 2020) - Khandebharad, Amol U.
Abstract: The impact of the trace quantity of water into the ionic liquid (IL) was investigated for the synthesis of highly substituted pyridine by the one pot three component condensation of aldehyde, malononitrile and thiophenol at reflux temperature. Water shown much more dramatic acceleration effect on the catalytic activity of choline hydroxide (ChOH) by diffusion of ions. This novel methodology describes the formation of the micro-heterogenous component by water depleted IL media. The present protocol offers a formation of new C-C and C-S bond, undoubtedly point out the task and recyclability of choline hydroxide.