Green and Convenient One-Pot Access to Polyfunctionalized Piperidine Scaffolds via Glutamic Acid Catalyzed Knoevenagel- Intramolecular [4+2] aza-Diels-Alder Imin-Based Multi-Component Reaction Under Ambient Temperature. (26th May 2020)

• Record Type: Journal Article
• Authors: Mohamadpour, Farzaneh
• Is Part Of: Polycyclic aromatic compounds. Volume 40:Number 3(2020)
• Page Start: 681
• Page End: 692
• Publication Date: 2020-05-26
• Subjects: Eco-safe and convenient synthesis -- Glutamic acid -- Green and biodegradable α-amino acid catalyst -- Polyfunctionalized piperidines -- Sustainable procedure; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2018.1472111
• Languages: English
• ISSNs: 1040-6638

Abstract

ABSTRACT: A catalytic methodology is reported that enables the green, operationally simple and convenient synthesis of corresponding polyfunctionalized piperidine scaffolds via one-pot Knoevenagel- intramolecular [4+2] aza-Diels-Alder imin-based multi-component reaction of between β-ketoesters, aromatic aldehydes and various amines, including some relevant drugs and pharmacologically active derivatives in the presence of biologically active α-amino acid, glutamic acid as a green and biodegradable catalyst. Remarkable E factors, green, readily and inexpensive catalyst, short reaction times, high to excellent yields, mild reaction conditions, high atom-economy and easy isolation procedures are key features of this methodology.