Amplitude of low‐frequency fluctuation of resting‐state fMRI in primary nocturnal enuresis and attention deficit hyperactivity disorder. Issue 3 (22nd April 2020)

• Record Type: Journal Article
• Authors: Jiang, Kaihua; Wang, Jianbao; Zheng, Aibin; Li, Lin; Yi, Yang; Ding, Li; Li, Hongxin; Dong, Xuan; Zang, Yufeng
• Is Part Of: International journal of developmental neuroscience. Issue 80:Issue 3(2020:May)
• Page Start: 235
• Page End: 245
• Publication Date: 2020-04-22
• Subjects: amplitude of low‐frequency fluctuation -- attention deficit hyperactivity disorder -- nocturnal enuresis -- resting‐state functional magnetic resonance imaging; Developmental neurobiology -- Periodicals; Neurology -- Periodicals; Neurologie du développement -- Périodiques; Developmental neurobiology; Periodicals; 612.8
• DOI: 10.1002/jdn.10020
• Languages: English
• ISSNs: 0736-5748

Abstract

Abstract: Children with attention deficit hyperactivity disorder (ADHD) and nocturnal enuresis (NE) have similar symptoms, for example, inattention and dysfunction of working memory. We investigate disorder‐specific abnormal activity by using the simple resting‐state functional magnetic resonance imaging (RS‐fMRI) metric amplitude of low‐frequency fluctuation (ALFF). About 18 ADHD, NE, and typically developing children were examined by RS‐fMRI and the child behavior checklist (CBCL) test. One‐way ANOVA were used to compare the ALFF values of the three groups and post hoc was done. We conducted Pearson correlation analysis on the results of the three groups' scales with ALFF values at the discrepant brain areas after then. Significant group effect was found in the bilateral medial prefrontal cortex (MPFC), left inferior temporal gyrus (ITG), left middle temporal gyrus (MTG), cerebellum anterior lobe (CAL), and left inferior parietal lobule (IPL). There was no shared abnormal region for ADHD and NE. Specially, ADHD showed increased ALFF in the bilateral MPFC, left ITG, and CAL and showed decreased ALFF in the left MTG. The children with NE showed increased ALFF in the left IPL. This study reveals the brain mechanism of cognitive changes on ADHD and NE, which provides neuroimaging basis for behavioral differences among different diseases. Abstract : The five brain regions showed the different brain activities between ADHD, NE, and healthy children. And the values of ALFF in the brain regions reflect the degrees of cognitive dysfunctions of these children.