An overview of in vivo toxicological profile of thymoquinone. (2nd April 2020)

• Record Type: Journal Article
• Authors: Mashayekhi-Sardoo, Habibeh; Rezaee, Ramin; Karimi, Gholamreza
• Is Part Of: Toxin reviews. Volume 39:Number 2(2020)
• Page Start: 115
• Page End: 122
• Publication Date: 2020-04-02
• Subjects: Thymoquinone -- Nigella sativa -- acute toxicity -- subacute toxicity -- subchronic toxicity; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2018.1514637
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: Thymoquinone (TQ) is a naturally occurring quinone derivative and its metabolism may produce reactive oxygen species which in turn may lead to various adverse effects. Here, we discuss in vivo data concerning toxicological effects of TQ. Previous studies showed LD50 values of 250–794 mg/kg in rats and 300–2400 mg/kg in mice for oral TQ but 57 mg/kg in rats and 90.3–104 mg/kg in mice for intraperitoneal TQ. In subacute toxicity evaluations, NOAEL was about 10 mg/kg. Though TQ has been found as an almost safe chemical, detailed studies are required before introducing TQ as a therapeutic agent for human use.