Feasibility of contrast-enhanced MRI derived textural features to predict overall survival in locally advanced breast cancer. (July 2020)

• Record Type: Journal Article
• Authors: Chronaiou, Ioanna; Giskeødegård, Guro Fanneløb; Goa, Pål Erik; Teruel, Jose; Hedayati, Roja; Lundgren, Steinar; Huuse, Else Marie; Pickles, Martin D; Gibbs, Peter; Sitter, Beathe; Bathen, Tone Frost
• Is Part Of: Acta radiologica. Volume 61:Number 7(2020)
• Page Start: 875
• Page End: 884
• Publication Date: 2020-07
• Subjects: Breast cancer -- magnetic resonance imaging -- texture analysis -- survival; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185119885116
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: The prognosis for women with locally advanced breast cancer (LABC) is poor and there is a need for better treatment stratification. Gray-level co-occurrence matrix (GLCM) texture analysis of magnetic resonance (MR) images has been shown to predict pathological response and could become useful in stratifying patients to more targeted treatments. Purpose: To evaluate the ability of GLCM textural features obtained before neoadjuvant chemotherapy to predict overall survival (OS) seven years after diagnosis of patients with LABC. Material and Methods: This retrospective study includes data from 55 patients with LABC. GLCM textural features were extracted from segmented tumors in pre-treatment dynamic contrast-enhanced 3-T MR images. Prediction of OS by GLCM textural features was assessed and compared to predictions using traditional clinical variables. Results: Linear mixed-effect models showed significant differences in five GLCM features (f1, f2, f5, f10, f11 ) between survivors and non-survivors. Using discriminant analysis for prediction of survival, GLCM features from 2 min post-contrast images achieved a classification accuracy of 73% ( P < 0.001), whereas traditional prognostic factors resulted in a classification accuracy of 67% ( P = 0.005). Using a combination of both yielded the highest classification accuracy (78%, P < 0.001). Median values for features f1, f2, f10, and f11 provided significantly different survival curves in Kaplan–Meier analysis. Conclusion: This study shows a clear association between textural features from post-contrast images obtained before neoadjuvant chemotherapy and OS seven years after diagnosis. Further studies in larger cohorts should be undertaken to investigate how this prognostic information can be used to benefit treatment stratification.