Pilot study of EEG in neonates born to mothers with gestational diabetes mellitus. Issue 66 (28th March 2018)

• Record Type: Journal Article
• Authors: Léveillé‐, Pauline; Hamel, Mathieu; Ardilouze, Jean‐Luc; Pasquier, Jean‐Charles; Deacon, Charles; Whittingstall, Kevin; Plourde, Mélanie
• Is Part Of: International journal of developmental neuroscience. Issue 66(2018:May)
• Page Start: 37
• Page End: 44
• Publication Date: 2018-03-28
• Subjects: Electroencephalogram -- Gestational diabetes mellitus -- Glucose control -- Newborn -- Power spectral density; Developmental neurobiology -- Periodicals; Neurology -- Periodicals; Neurologie du développement -- Périodiques; Developmental neurobiology; Periodicals; 612.8
• DOI: 10.1016/j.ijdevneu.2018.01.003
• Languages: English
• ISSNs: 0736-5748

Abstract

Abstract: Background: The goal was to evaluate whether there was neurodevelopmental deficits in newborns born to mothers with gestational diabetes mellitus (GDM) compared to control newborns born to healthy mothers. Methods: Forty‐six pregnant women (21 controls and 25 GDM) were recruited. Electroencephalogram (EEG) was recorded in the newborns within 48 h after birth. The EEG signal was quantitatively analyzed using power spectral density (PSD); coherence between hemispheres was calculated in paired channels of frontal, temporal, central and occipital regions. Results: The left centro‐occipital PSD in control newborns was 12% higher than in GDM newborns ( p = 0.036) but was not significant after adjustment for gestational age. While coherence was higher in the frontal regions compared to the occipital regions ( p < 0.001), there was no difference between the groups for the fronto‐temporal, frontal‐central, centro‐occipital and tempo‐occipital regions. Conclusion: Our results support that EEG differences between groups were mainly modified by gestational age and less by GDM status of the mothers. However, there is a need to confirm this result with a higher number of mother‐newborns. Quantitative EEG in GDM newborns within 48 h after birth is feasible. This study emphasizes the importance of controlling blood glucose during GDM to protect infant brain development.