Chidamide in combination with chemotherapy in refractory and relapsed T lymphoblastic lymphoma/leukemia. Issue 4 (20th March 2020)

• Record Type: Journal Article
• Authors: Guan, Wei; Jing, Yu; Dou, Liping; Wang, Maoquan; Xiao, Yang; Yu, Li
• Is Part Of: Leukemia & lymphoma. Volume 61:Issue 4(2020)
• Page Start: 855
• Page End: 861
• Publication Date: 2020-03-20
• Subjects: Precursor T-cell lymphoblastic leukemia-lymphoma -- early T-cell precursor acute lymphoblastic lymphoma/leukemia -- Chidamide -- salvage therapy -- hematopoietic stem cell transplantation; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2019.1691195
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Chidamide, a novel histone deacetylase inhibitor, has exerted effects in T-cell tumors through various mechanisms. Seventeen patients with refractory or relapsed T-cell acute lymphoblastic lymphoma/leukemia (T-LBL/ALL) received Chidamide combined with chemotherapy as salvage treatment. Historical data was analyzed as comparison as chemotherapy group. Complete response (CR) rate and overall response rate (ORR) of Chidamide + chemotherapy group were higher than that of chemotherapy group after one course. Chidamide + chemotherapy group had a better progress-free survival (PFS) compared to chemotherapy group. No difference in overall survival (OS) was observed. Grade 3/4 nonhematological adverse events (>10%) of patients in Chidamide + chemotherapy group included febrile neutropenia (64.7%), drug-induced liver failure (17.6%), decreased fibrinogen (11.8%), sepsis (11.8%), pneumonitis (11.8%), and oral mucositis (11.8%). This study demonstrates that Chidamide included regimen may be a new treatment strategy with an acceptable safety profile for refractory or relapsed T-LBL/ALL patients but requires further investigation.