Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation. Issue 10 (2nd July 2020)

• Record Type: Journal Article
• Authors: Sarfraz, Rai Muhammad; Khan, Muhammad Usman; Mahmood, Asif; Akram, Muhammad Rouf; Minhas, Muhammad Usman; QAISAR, Muhammad Naeem; ALI, Muhammad Rizwan; Ahmad, Hasnain; Zaman, Muhammad
• Is Part Of: Polymer-plastics technology and materials. Volume 59:Issue 10(2020)
• Page Start: 1109
• Page End: 1123
• Publication Date: 2020-07-02
• Subjects: Carbopol -- free radical polymerization -- ketoprofen -- methacrylic acid -- nanogels; Polymers -- Periodicals; Polymerization -- Periodicals; Plastics -- Periodicals; Plastics; Polymerization; Polymers; Periodicals; 668
• DOI: 10.1080/25740881.2020.1719148
• Languages: English
• ISSNs: 2574-0881

Abstract

ABSTRACT: Hydrogels nanoparticles of carbopol were prepared by free-radical polymerization technique. Methacrylic acid (MAA) imparted the pH-sensitive response to formulations. pH-sensitive behavior of the prepared formulations was evaluated by swelling index of the formulations at different pH 1.2 and 7.4 and it presented the maximum swelling index at pH 7.4. It was evident from the release behavior of drugs that maximum drug release was at higher pH 7.4, and less drug release at lower pH 1.2 that is acidic. Results of nanogels carrier systems are the indications of gastro-protective drug delivery of gastric irritant agent, ketoprofen. Graphical abstract: