Acylated flavonoid glycosides from Barringtonia racemosa. Issue 9 (2nd May 2020)

• Record Type: Journal Article
• Authors: Van, Quach Thi Thanh; Vien, Le Thi; Hanh, Tran Thi Hong; Huong, Phan Thi Thanh; Cuong, Nguyen The; Thao, Nguyen Phuong; Thuan, Nguyen Huy; Dang, Nguyen Hai; Thanh, Nguyen Van; Cuong, Nguyen Xuan; Nam, Nguyen Hoai; Kiem, Phan Van; Minh, Chau Van
• Is Part Of: Natural product research. Volume 34:Issue 9(2020)
• Page Start: 1276
• Page End: 1281
• Publication Date: 2020-05-02
• Subjects: Barringtonia racemosa -- Lecythidaceae -- flavonoid glycoside -- NO production; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1560290
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Using various chromatographic separations, three new acylated flavonoid glycosides, namely barringosides G–I (1 –3 ), were isolated from the water-soluble extract of Barringtonia racemosa branches and leaves. The structure elucidation was performed by extensive analysis of the 1D and 2D NMR and HR-QTOF-MS data. Of the isolated compounds, barringoside I (3 ) showed moderate inhibitory effects on LPS-induced NO production in RAW264.7 cells with an IC50 of 52.48 ± 1.04 µM. Graphical Abstract: