Cytotoxic Activity of Selected Nigerian Medicinal Plants. Issue 2 (2nd April 2020)

• Record Type: Journal Article
• Authors: Aladesanmi, Adetunji Joseph; Famuyiwa, Funmilayo Gladys; Oriola, Ayodeji Oluwabunmi; Oguntimehin, Samuel Ayoolu; Aiyedun, Priscilla Oluwakemi; Arthur, Gilbert
• Is Part Of: Journal of herbs, spices & medicinal plants. Volume 26:Issue 2(2020)
• Page Start: 203
• Page End: 217
• Publication Date: 2020-04-02
• Subjects: Cancer -- MTS assay; Medicinal plants -- Periodicals; Herbs -- Periodicals; Spices -- Periodicals; 581.63
• DOI: 10.1080/10496475.2019.1706214
• Languages: English
• ISSNs: 1049-6475

Abstract

ABSTRACT: The study investigated eight Nigerian medicinal plants: Artocarpus communis fruit (Ac-F), Cassia sieberiana root bark (Cs-R), Eugenia uniflora leaf (Eu-L), Hibiscus rosa-sinensis flower (Hr-F), Laportea aestuans aerial part (La-A), Massularia acuminata stem bark (Ma-S), Trichilia heudelotii leaf (Th-L), and Xylopia aethiopica fruit (Xa-F), for anticancer activity. The alcoholic extracts of the plants were tested against human prostate DU-145, breast JIMT-1, and pancreatic BxPC-3 cancer cell lines using Methanethiosulfonate (MTS) assay, where chlorambucil was used as positive control. The active fractions were solvent-partitioned and tested against the three cancer cell lines. The results showed a concentration dependent decrease in cancer cell viability and cytotoxicity of four of the extracts, namely Massularia acuminata stem bark (Ma-S), Xylopia aethioipica fruit (Xa-F), Laportea aestuans aerial part (La-A), and Eugenia uniflora leaf (Eu-L). The petroleum ether fraction of X. aethiopica fruit (XP) demonstrated the greatest anticancer activity. At 75 µg mL −1, XP (37.2 ± 4.4%) was comparable to chlorambucil (39.88 ± 2.41%), in its cytotoxicity against breast cancer cell line JIMT-1.