Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death. Issue 9 (1st September 2020)

• Record Type: Journal Article
• Authors: Zhang, Yi-Ming; Shi, Xiao-Bing; Xu, Bo; Yuan, Cheng-Shan; Zheng, Wei; Li, Gang; Li, Ji; Wang, Zhen-Hua
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 9(2020)
• Page Start: 850
• Page End: 863
• Publication Date: 2020-09-01
• Subjects: B16-F10 melanoma cells -- xanthohumol -- endoplasmic reticulum stress -- non-apoptosis death; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1644623
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. Further investigation showed XN inhibited cell proliferation in a time- and dose-dependent manner along with down-regulation of mitogen-activated protein kinase and up-regulation of the endoplasmic reticulum (ER) stress marker Bip, CHOP and protein ubiquitination, which was relieved by the ER-stress inhibitor 4-PBA. Whereas no early apoptosis characteristics was identified during XN induced cell death.