Block copolymer@ZIF-8 nanocomposites as a pH-responsive multi-steps release system for controlled drug delivery. Issue 6 (12th April 2020)

• Record Type: Journal Article
• Authors: Lei, Zhentao; Tang, Qiuju; Ju, Yanshan; Lin, Yonghui; Bai, Xiaowen; Luo, Haipeng; Tong, Zaizai
• Is Part Of: Journal of biomaterials science. Volume 31:Issue 6(2020)
• Page Start: 695
• Page End: 711
• Publication Date: 2020-04-12
• Subjects: Core-shell nanoparticles -- block copolymer -- zeolitic imidazolate frameworks-8 -- drug delivery -- pH-responsiveness; Polymers -- Biocompatibility -- Periodicals; Biomedical materials -- Periodicals; 572.33
• DOI: 10.1080/09205063.2020.1713451
• Languages: English
• ISSNs: 0920-5063

Abstract

Abstract: Developing the hybrid nanosystems for controlled drug release is still a challenging task. In this work, pH-responsive core-shell nanocomposites have been prepared by the growth of zeolitic imidazolate framework-8 (ZIF-8) on the surface of polymeric aggregates self-assembled from poly(ε-caprolactone)- block -poly ( quaternized vinylbenzyl chloride/bipyridine) (PCL- b - q (PVBC/BPy), BCP for short) in water. The core of the micelles or the inner cavity of vesicles serves as the drug storage reservoir for the doxorubicin hydrochloride (DOX) and the ZIF-8 shells act as the gatekeepers to prevent drug premature release at physiological environment. Upon pH stimulus, the core-shell nanocomposites (BCP@ZIF-8) show a retarded drug release behavior compared with DOX-loaded polymeric aggregates counterparts (without the shell of ZIF-8). Moreover, the as-prepared nanocomposites perform good biocompatibility towards MCF-7 cell. Meanwhile, the DOX-loaded BCP@ZIF-8 nanocomposites present lower cytotoxicity compared with DOX-loaded BCP and free DOX. The confocal microscopy study shows the core-shell nanocomposites could be efficiently internalized by cancer cells, and the loaded DOX could be successfully released under acidic intracellular environment. The above result shows that the core-shell nanocomposite could be a promising candidate for pH-responsive drug delivery system in the cancer therapy.