UNIT 2.15 DNA Motif Databases and Their Uses. Issue 1 (3rd September 2015)

• Record Type: Journal Article
• Authors: Stormo, Gary D.
• Is Part Of: Current protocols in bioinformatics. Volume 51:Issue 1(2015)
• Page Start: 2.15.1
• Page End: 2.15.6
• Publication Date: 2015-09-03
• Subjects: transcription factors -- DNA motifs -- position weight matrices -- binding site predictions; Bioinformatics -- Laboratory manuals; Nucleotide sequence -- Laboratory manuals; Amino acid sequence -- Laboratory manuals; Base Sequence; Amino Acid Sequence; Computational Biology -- methods; Databases, Genetic; Proteins -- analysis; Sequence Analysis -- methods; Sequence Homology; Amino acid sequence; Bioinformatics; Nucleotide sequence; Laboratory Manuals; Laboratory manuals; 570.285
• DOI: 10.1002/0471250953.bi0215s51
• Languages: English
• ISSNs: 1934-3396

Abstract

Abstract : Transcription factors (TFs) recognize and bind to specific DNA sequences. The specificity of a TF is usually represented as a position weight matrix (PWM). Several databases of DNA motifs exist and are used in biological research to address important biological questions. This overview describes PWMs and some of the most commonly used motif databases, as well as a few of their common applications. © 2015 by John Wiley & Sons, Inc.