Permeability quantification of porous polymer scaffold for bone tissue engineering. (2020)

• Record Type: Journal Article
• Authors: Pasha Mahammod, Babar; Barua, Emon; Deoghare, Ashish B.; Pandey, K.M.
• Is Part Of: Materials today. Volume 22:Part 4(2020)
• Page Start: 1687
• Page End: 1693
• Publication Date: 2020
• Subjects: Porous scaffold -- Permeability -- solvent casting particulate leaching method -- micro-CT -- Computational fluid dynamics; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2020.02.186
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: In the present study, a computational fluid dynamic approach is used to investigate permeability of Hydroxyapatite (HA)-Poly(methyl methacrylate (PMMA) porous scaffold. The scaffold used in this work is prepared by solvent castingparticulate leaching method (SCPL). The porosity of the scaffold is 65% with an average pore diameter of 250 µm. The 3D micro-geometry of the scaffold is reconstructed from 250 high-resolution micro-CT images with a resolution of 37 µm. Image processing software Mimics 12.0 is used for segmentation of the images. The CFD simulations performed on a selected region of interest to limit boundary effects. The permeability of the scaffold estimated using blood flow properties. The CFD analysis carried out by considering fluid domain as two cases. Classical Darcy's law used for Newtonian model and modified Darcy's law is used for non-Newtonian model to quantify the permeability of the scaffold.From the results, it is found that the permeability in the caseof Newtonian scaffold model is more than the non-Newtonian scaffold model