Acute Cardiac Rejection: Antagomir‐155 Attenuates Acute Cardiac Rejection Using Ultrasound Targeted Microbubbles Destruction (Adv. Healthcare Mater. 14/2020). Issue 14 (22nd July 2020) - Yi, Luyang
Abstract : In article number 2000189 by Li Zhang, Mingxing Xie, and co‐workers, cationic microbubbles composed of DOTAP, DSPC, and DSPE‐PEG2000 are synthesized to carry antagomir‐155 and deliver it to allograft heart in a murine model by ultrasound targeted microbubbles destruction (UTMD). Sonoporation and cavitation make antagomir‐155 penetrate vascular endothelium into intracellular region of allograft heart. This therapy downregulates microRNA‐155 level in graft heart and attenuates degree of acute cardiac rejection.