P161 - Quantitative metabolic profiling of slowly cleared chemicals in in vitro models including 3D liver spheroid and hepatopac and hepatic clearance predictions from in vitro data using gastroplus PBPK modelling following topical application. (2020) - Lee, Mi-Young; Martin, Sue; Pickles, Juliette; Rigarlsford, Annabel; Sorrell, Ian; Herédi-Szabó, Krisztina; Kalapos-Kovács, Bernadett; Cubberley, Richard