Two new phenylethanoid glycosides from Ginkgo biloba leaves and their tyrosinase inhibitory activities. (August 2020)

• Record Type: Journal Article
• Authors: Shu, Penghua; Fei, Yingying; Li, Junping; Liu, Anqi; Zhang, Lingxiang; Niu, Haoying; Liu, Wanrong; Wei, Xialan; Xiao, Fugang; Xu, Zhihong
• Is Part Of: Carbohydrate research. Volume 494(2020)
• Publication Date: 2020-08
• Subjects: Ginkgo biloba -- Tyrosinase -- Antioxidants -- Hydrolysis -- Glycosides; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2020.108059
• Languages: English
• ISSNs: 0008-6215

Abstract

Abstract: Two undescribed phenylethanoid glycosides, Ginkgoside C (1 ) and D (2 ), together with ten known glycosides (3 −12 ) were isolated from Ginkgo biloba leaves. Their structures were characterized by physical data analyses such as NMR, HRESIMS, as well as chemical hydrolysis. All compounds were tested for their tyrosinase inhibitory activities. At a concentration of 25 μ M, compounds 2, 4, 5, 6, and 11 showed obvious mushroom tyrosinase inhibition activities, with %inhibition values of 19.12 ± 2.59%, 25.79 ± 1.83%, 16.07 ± 1.07%, 24.46 ± 1.10%, 18.64 ± 3.62%, respectively, with kojic acid used as the positive control (27.50 ± 2.72%). Graphical abstract: Image 1 Highlights: Two new phenylethanoid glycosides (1 –2 ) and ten known glycosides (3 −12 ) were isolated from the leaves of Ginkgo biloba. The structures of new compounds (1 –2 ) were determined by HRESIMS, NMR, acid hydrolysis, and comparisons with literatures. Compounds 2, 4 –6, and 11 exhibited obvious mushroom tyrosinase inhibition activities.