Angiostrongyliasis detected by next-generation sequencing in a ELISA-negative eosinophilic meningitis: A case report. (August 2020)

• Record Type: Journal Article
• Authors: Zou, Yueli; Guan, Hongzhi; Wu, Honglong; Bu, Hui; Yan, Litian; Zhu, Yifei; He, Junying
• Is Part Of: International journal of infectious diseases. Volume 97(2020)
• Page Start: 177
• Page End: 179
• Publication Date: 2020-08
• Subjects: Eosinophilic meningitis -- Cerebrospinal fluid -- Next-generation sequencing; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2020.05.108
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: This case reported enzyme-linked immunosorbent assay (ELISA)-negative next-generation sequencing (NGS)-positive cerebral Angiostrongylus cantonensis . Angiostrongylus cantonensis was detected by NGS of the cerebrospinal fluid. NGS is a tool for etiological diagnosis. Abstract: Next-generation sequencing (NGS) is an emerging method with the potential of pan-pathogen screening. This study described a case of eosinophilic meningitis (EoM) with enzyme-linked immunosorbent assay (ELISA)-negative results for Angiostrongylus cantonensis ( A. cantonensis ), Trichinella spiralis and Paragonimus westermani and a positive identification of A. cantonensis by NGS in the cerebrospinal fluid .