Multisystem Inflammatory Syndrome in Children (MIS-C) with COVID-19: Insights from simultaneous familial Kawasaki Disease cases. (August 2020)

• Record Type: Journal Article
• Authors: Ebina-Shibuya, R.; Namkoong, H.; Shibuya, Y.; Horita, N.
• Is Part Of: International journal of infectious diseases. Volume 97(2020)
• Page Start: 371
• Page End: 373
• Publication Date: 2020-08
• Subjects: COVID-19 -- SARS-CoV-2 -- Multisystem Inflammatory Syndrome in Children (MIS-C) -- Kawasaki Disease; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2020.06.014
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: SARS-CoV-2 causes Multisystem Inflammatory Syndrome in Children (MIS-C). MIS-C includes common with or distinct from symptoms of Kawasaki Disease (KD). Several simultaneous familial KD cases are summarized here. MIS-C and KD are discussed as an interplay of infection and genetic factors of hosts. COVID-19, KD, BCG or measles might have some crosstalk in immune responses. Abstract: Recently, an increasing number of SARS-CoV-2 patients with COVID-19 syndrome, which overlaps with Kawasaki Disease (KD), have been reported, supporting the suggestion that infection is one of the triggers of KD. We summarized the reports of simultaneous familial KD cases to better understand the etiopathogenesis of both KD and Multisystem Inflammatory Syndrome in Children (MIS-C) related to COVID-19. Here we discuss the etiology of these syndromes from the point of view of infection and genetic susceptibility.