Uncovering the Modulatory Interactions of Brain Networks in Cognition with Central Thalamic Deep Brain Stimulation Using Functional Magnetic Resonance Imaging. (1st August 2020)

• Record Type: Journal Article
• Authors: Li, Ssu-Ju; Lo, Yu-Chun; Lai, Hsin-Yi; Lin, Sheng-Huang; Lin, Hui-Ching; Lin, Ting-Chun; Chang, Ching-Wen; Chen, Ting-Chieh; Chin-Jung Hsieh, Christine; Yang, Shih-Hung; Chiu, Feng-Mao; Kuo, Chao-Hung; Chen, You-Yin
• Is Part Of: Neuroscience. Volume 440(2020)
• Page Start: 65
• Page End: 84
• Publication Date: 2020-08-01
• Subjects: 1D one-dimensional -- 3D three-dimensional -- α4-nAChR alpha 4 nicotinic acetylcholine receptor -- ACC anterior cingulate cortex -- AFNI Analysis of Functional NeuroImages -- BOLD blood oxygen level dependent -- CA1 hippocampal cornu ammonis 1 -- CA2 hippocampal cornu ammonis 2 -- CA3 hippocampal cornu ammonis 3 -- CL central lateral nucleus -- CM central medial nucleus -- CPu caudate putamen -- CT-DBS central thalamic deep brain stimulation -- CT central thalamus -- DBS deep brain stimulation -- Drd1 dopamine receptor D1 -- Drd2 dopamine receptor D2 -- EDTA ethylenediaminetetraacetic acid -- FASTMAP fast automated shimming technique by mapping along projections -- FC functional connectivity -- FDR false discovery rate -- fMRI functional magnetic resonance imaging -- FOV field of view -- FSL FMRIB Software Library -- FWHM full-width half maximum -- GE-EPI gradient echo-echo planar imaging -- Hip hippocampus -- HRP horseradish peroxidase -- HypoTH hypothalamus -- Ig immunoglobulin -- LFP local field potential -- LTP long-term potentiation -- M1 motor cortex -- Me[Q1–Q3] medians with interquartile ranges -- MR magnetic resonance -- MRI magnetic resonance imaging -- Pf parafascicular nucleus -- PMSF phenylmethylsulfonyl fluoride -- Po posterior thalamus -- Re reuniens nucleus -- REM rapid eye movement -- RF radiofrequency -- Rh rhomboid nucleus -- ROIs regions of interests -- rsfMRI resting-state fMRI -- S1 primary somatosensory cortex -- S2 secondary somatosensory cortex -- SC somatosensory cortices -- SEM standard error of the mean -- SDS-PAGE sodium dodecyl sulfate polyacrylamide gel electrophoresis -- TH thalamus -- Tris-HCl Tris hydrochloride -- TSE turbo spin echo -- VPM ventral posteromedial nucleus; central thalamus -- deep brain stimulation -- neural probe -- resting-state fMRI -- magnetic resonance compatibility -- functional connectivity; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2020.05.022
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: CT-DBS increases in the functional connectivity of the corticostriatal, corticolimbic, and thalamocortical networks. CT-DBS enhances the cognitive function of learning and memory. Changes in the dopamine receptors after CT-DBS suggest that CT-DBS alters the synapse plasticity. Abstract: Deep brain stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. It acts by altering brain networks and facilitating synaptic plasticity. For enhancing cognitive functions, the central thalamus (CT) has been shown to be a potential DBS target. The network-level mechanisms contributing to the effect exerted by DBS on the CT (CT-DBS) remain unknown. Combining CT-DBS with functional magnetic resonance imaging (fMRI), this study explored brain areas activated while applying CT-DBS in rats, using a newly developed neural probe that was compatible with MRI and could minimize the image distortion and resolve safety issues. Results showed activation of the anterior cingulate cortex, motor cortex, primary and secondary somatosensory cortices, caudate putamen, hypothalamus, thalamus, and hippocampus, suggesting that the corticostriatal, corticolimbic, and thalamocortical brain networks were affected. Behaviorally, the CT-DBS group required a shorter time than sham controls to learn a water-reward lever-pressing task and made more correct choices in a T-maze task. Concurrent with enhanced learning performance, bilateral CT-DBS resulted in alteration in the functional connectivity of brain networks determined by resting-state fMRI. Western blot analyses showed that the protein level of both dopamine D1 and α4-nicotinic acetylcholine receptors was increased, and dopamine D2 receptor was decreased. These data suggest that CT-DBS can enhance cognitive performance as well as brain connectivity through the modulation of synaptic plasticity, such that CT is a target providing high potential for the remediation of acquired cognitive learning and memory disabilities.