Chemical constituents of the fruits of Gambeya lacourtiana (Sapotaceae). (August 2020)

• Record Type: Journal Article
• Authors: Talla, Rostan Mangoua; Jouda, Jean-Bosco; Mawabo, Isabelle Kamga; Tegasne, Catherine; Happi, Gervais Mouthé; Lenta, Bruno Ndjakou; Kapche, Gilbert Deccaux Wabo Fotso; Frese, Marcel; Wandji, Jean; Sewald, Norbert
• Is Part Of: Phytochemistry letters. Volume 38(2020)
• Page Start: 84
• Page End: 89
• Publication Date: 2020-08
• Subjects: Lacourtianol -- lacourtianoside -- lacourtianamide -- Gambeya lacourtiana -- Sapotaceae; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2020.05.009
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Isolation of 4 new compounds from the fruits of Gambeya lacourtiana (Sapotaceae). First report of cerebrosides and ceramide in the genus Gambeya . Moderate antibacterial activity of lacourtianoside II. MS/MS fragmentation of compounds 1, 2 and 4 Abstract: Phytochemical investigation of the fruits of Gambeya lacourtiana led to the isolation of four new compounds, lacourtianol (1), lacourtianoside I (2), lacourtianoside II (3) and lacourtianamide (4) together with six known compounds: 3- O -acetylbetulin (5), 3- O -acetylerythrodiol (6), β -amyrincaproate (7), lupeolhexanoate (8), erythrodiol 3- O -palmitate (9), and D -mannitol (10) . The structures of 1 -10 were elucidated on the basis of 1D and 2D NMR spectroscopic data, mass spectrometry and by comparison of spectroscopic data with those from the literature. Compounds 1 -10 were evaluated for their antibacterial activity. Lacourtianoside II (3 ) exhibited moderate activity against Salmonella typhi CHU, Staphylococcus aureus (ATCC 43300 and ATCC 25923) and Enterobacter cloacae k2 with the same MIC value of 22.3 μM.