Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and related conditions. (September 2020)

• Record Type: Journal Article
• Authors: Noroozi, Rezvan; Branicki, Wojciech; Pyrc, Krzysztof; Łabaj, Paweł P.; Pospiech, Ewelina; Taheri, Mohammad; Ghafouri-Fard, Soudeh
• Is Part Of: Cytokine. Volume 133(2020)
• Publication Date: 2020-09
• Subjects: SARS-CoV -- Cytokine -- Immune cells; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2020.155143
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: SARS-CoV-2 causes dysregulation of immune responses in severely affected patients. Elevated levels of IL-6 and IL-10 predict severe course of the disorder. Immune responses have indispensable functions in the determination of course of SARS-CoV infection. Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in early 2020. The infection has been associated with a wide range of clinical symptoms. In the severely affected patients, it has caused dysregulation of immune responses including over-secretion of inflammatory cytokines and imbalances in the proportion of naïve helper T cells, memory helper T cells and regulatory T cells. Identification of the underlying mechanism of such aberrant function of immune system would help in the prediction of disease course and selection of susceptible patients for more intensive cares. In the current review, we summarize the results of studies which reported alterations in cytokine levels and immune cell functions in patients affected with SARS-CoV-2 and related viruses.