Frontispiece: Mechanochemical Synthesis of Short DNA Fragments. Issue 41 (20th July 2020)

• Record Type: Journal Article
• Authors: Thorpe, James D.; O'Reilly, Daniel; Friščić, Tomislav; Damha, Masad J.
• Is Part Of: Chemistry. Volume 26:Issue 41(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-20
• Subjects: DNA -- green chemistry -- H-phosphonate -- mechanochemistry -- phosphoramidite; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202084163
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : A "Mill & Shake" process to make DNA fragments : This study demonstrates that di‐ and trinucleotides can be assembled under ball‐milling conditions by multi‐step reactions, in a one‐pot fashion, and in the absence of bulk solvents. The process is fully compatible with H‐phosphonate and phosphoramidite chemistries, currently applied to oligo‐DNA and RNA synthesis. For more information, see the Communication by M. J. Damha et al. on page 8857 ff.