Viral Vectors for Gene Transfer. Issue 4 (28th November 2018)

• Record Type: Journal Article
• Authors: Chen, Yong Hong; Keiser, Megan S.; Davidson, Beverly L.
• Editors: Auwerx, Johan; Ackerman, Susan L.; Brown, Stephen D.; Justice, Monica J.; Nadeau, Joseph
• Is Part Of: Current protocols in mouse biology. Volume 8:Issue 4(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-11-28
• Subjects: adeno‐associated viruses -- adeno‐viruses -- gene therapy -- lentiviruses -- retroviruses -- viral vector; Mice -- Genetics -- Laboratory manuals; Mice; Animals, Laboratory; Research; Mice -- Genetics; Periodicals; Laboratory manuals; 616.027333
• DOI: 10.1002/cpmo.58
• Languages: English
• ISSNs: 2161-2617

Abstract

Abstract: Viral vectors are a promising tool for effective delivery of genetic material into cells. They take advantage of the natural ability of a virus to deliver a genetic payload into cells while being genetically modified such that their ability to replicate is crippled or removed. Here, an updated overview of routinely used viral vectors, including adeno‐associated viruses (AAV), retroviruses/lentiviruses, and adenoviruses (Ads), is provided, as well as perspectives on their advantages and disadvantages in research and gene therapy. © 2018 by John Wiley & Sons, Inc.