Prime Editing: A New Way for Genome Editing. Issue 4 (April 2020)

• Record Type: Journal Article
• Authors: Marzec, Marek; Brąszewska-Zalewska, Agnieszka; Hensel, Goetz
• Is Part Of: Trends in cell biology. Volume 30:Issue 4(2020)
• Page Start: 257
• Page End: 259
• Publication Date: 2020-04
• Subjects: CRISPR-Cas9 -- genome editing -- prime editing -- targeted mutagenesis; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2020.01.004
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : Precise and efficient use of genome editing tools are hampered by the introduction of DNA double-strand breaks, donor DNA templates, or homology-directed repair. A recent study expands the genome editing toolbox with the introduction of prime editing, which overcomes previous challenges and introduces insertions, deletions, and all putative 12 types of base-to-base conversions in human cells.