Oscillotherapeutics – Time-targeted interventions in epilepsy and beyond. (March 2020)

• Record Type: Journal Article
• Authors: Takeuchi, Yuichi; Berényi, Antal
• Is Part Of: Neuroscience research. Volume 152(2020)
• Page Start: 87
• Page End: 107
• Publication Date: 2020-03
• Subjects: 6-OHDA 6-hydroxydopamine -- AI artificial intelligence -- AD Alzheimer's disease -- AMY amygdala -- BDNF brain-derived neurotrophic factor -- CSFA cross-spectral factor analysis -- CSTC corticostriatal-thalamocortical -- DBS deep brain stimulation -- DLPFC dorsolateral prefrontal cortex -- DMN default mode network -- DSM-5 diagnostic and statistical manual of mental disorders -- DSP digital signal processor -- DRT dopamine replacement therapy -- ECN executive control network -- ECoG electrocorticography -- ECT electroconvulsive therapy -- EEG electroencephalography -- FDA food and drug administration -- fMRI functional magnetic resonance imaging -- FPGA field-programmable gate array -- GAD generalized anxiety disorder -- GPU graphical processing unit -- HD-tACS high definition transcranial alternating current stimulation -- HD-tDCS high definition transcranial direct current stimulation -- HPC hippocampus -- ICA independent component analysis -- IoT internet of things -- ISP intersectional-short pulse -- LFP local field potential -- MAM methylazoxymethanol acetate -- MDD major depressive disorder -- MEG magnetoencephalography -- MS medial septum -- MPTP 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine -- NAc nucleus accumbens -- PCA principal component analysis -- PCP phencyclidine -- PD Parkinson's disease -- PFC prefrontal cortex -- PTSD posttraumatic stress disorders -- PTZ pentylenetetrazole -- PV parvalbumine -- REM rapid eye movement -- rTMS repetitive transcranial magnetic stimulation -- SNc substantia nigra pars compacta -- STN subthalamic nucleus -- SUDEP sudden unexpected death in epilepsy -- tACS transcranial alternating current stimulation -- tDCS transcranial direct current stimulation -- TES transcranial electrical stimulation -- tFUS transcranial focused ultrasound stimulation -- TI temporal interference -- TMS transcranial magnetic stimulation; Oscillation -- Closed-loop intervention -- Transcranial electrical stimulation -- Neuromodulation -- Epilepsy -- Psychiatric disorders -- Oscillopathy -- Oscillotherapeutics; Neurosciences -- Research -- Periodicals; Neurosciences -- Research -- Japan -- Periodicals; Neurology -- Periodicals; Neurosciences -- Periodicals; Neurosciences -- Recherche -- Périodiques; Neurosciences -- Recherche -- Japon -- Périodiques; Neurosciences -- Research; Japan; Periodicals; 612.8
• DOI: 10.1016/j.neures.2020.01.002
• Languages: English
• ISSNs: 0168-0102

Abstract

Highlights: Neurological and psychiatric disorders have oscillation disturbances in common. Interfering with physiological oscillations may reveal disease mechanisms. Intervention or modulation of pathological oscillations may alleviate symptoms. A time-targeted focused transcranial electrical stimulation (TES) has emerged. Devices for the time- and space-targeted TES are under development. Abstract: Oscillatory brain activities support many physiological functions from motor control to cognition. Disruptions of the normal oscillatory brain activities are commonly observed in neurological and psychiatric disorders including epilepsy, Parkinson's disease, Alzheimer's disease, schizophrenia, anxiety/trauma-related disorders, major depressive disorders, and drug addiction. Therefore, these disorders can be considered as common oscillation defects despite having distinct behavioral manifestations and genetic causes. Recent technical advances of neuronal activity recording and analysis have allowed us to study the pathological oscillations of each disorder as a possible biomarker of symptoms. Furthermore, recent advances in brain stimulation technologies enable time- and space-targeted interventions of the pathological oscillations of both neurological disorders and psychiatric disorders as possible targets for regulating their symptoms.