Endoplasmic Reticulum Protein Quality Control in β Cells. (July 2020)

• Record Type: Journal Article
• Authors: Shrestha, Neha; Reinert, Rachel B.; Qi, Ling
• Is Part Of: Seminars in cell & developmental biology. Volume 103(2020)
• Page Start: 59
• Page End: 67
• Publication Date: 2020-07
• Subjects: diabetes -- β cells -- ER -- UPR -- ER-phagy -- ERAD; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2020.04.006
• Languages: English
• ISSNs: 1084-9521

Abstract

ABSTRACT: Type 1 and type 2 diabetes are associated with loss of β cell function. Optimal β cell function is linked to protein homeostasis in the endoplasmic reticulum (ER). Here, we review the roles of ER protein quality-control mechanisms, including the unfolded protein response (UPR), autophagy (specifically ER-phagy) and ER-associated degradation (ERAD), in β cells. We propose that different quality control mechanisms may control different aspects of β cell biology (i.e. function, survival, and identity), thereby contributing to disease pathogenesis.