Does SEN-V and other non-A-E hepatotropic viruses contribute to the development and progression of non-alcoholic fatty liver disease?. (April 2020)

• Record Type: Journal Article
• Authors: Grubert Van Iderstine, M.; Osiowy, C.; Rumbolt, C.; Zhang, M.; Swidinsky, K.; Kaita, K.D.E.; Minuk, G.Y.
• Is Part Of: Medical hypotheses. Volume 137(2020)
• Publication Date: 2020-04
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Medicine; Periodicals; 610
• DOI: 10.1016/j.mehy.2019.109528
• Languages: English
• ISSNs: 0306-9877

Abstract

Abstract: Approximately 10–20% of patients with non-alcoholic fatty liver disease (NAFLD) are at risk of progressing to cirrhosis. The cause of such progression is unclear. SEN-V is a hepatotropic virus that has been associated with more severe and advanced liver disease in patients with chronic hepatitis C virus infections. In this study we tested 32 NAFLD patients for evidence of SEN-V infection and correlated the results with histologic findings. The results of the study revealed similar disease severity and stage of progression in SEN-V positive and negative patients. Although not supportive of our hypothesis, the possibility that SEN-V and/or other non-A-E hepatotropic viruses contribute to the development and course of NAFLD is discussed.