The acquisition of trisomy 8 associated with Behçet's-like disease in myelodysplastic syndrome. (2020)

• Record Type: Journal Article
• Authors: Oka, Satoko; Ono, Kazuo; Nohgawa, Masaharu
• Is Part Of: Leukemia research reports. Volume 13(2020)
• Publication Date: 2020
• Subjects: Behçet's disease -- Myelodysplastic syndrome (MDS) -- Trisomy 8; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2020.100196
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: A relationship has been reported between myelodysplastic syndrome (MDS) and autoimmune disease. Behçet's disease is a multisystem inflammatory disorder with mucocutaneous, articular, gastrointestinal, neurological, and vascular manifestations. The co-occurrence of MDS with trisomy 8 and Behçet's-like disease was recently demonstrated. We herein describe a case that shows the relationship between the acquisition of trisomy 8 and occurrence of Behçet's-like disease. Immune dysregulation and altered T-cell hemostasis play an important role in the pathogenesis of Behçet's-like disease and MDS with trisomy 8.