Oyster hydrolysate-zinc complex ameliorates carrageenan-induced rat prostatitis via an anti-inflammatory mechanism and reduced oxidative stress. (September 2020)

• Record Type: Journal Article
• Authors: Feng, Yinong; Jiang, Suisui; Wang, Zhe; Li, Shiyang; Liu, Zunying; Zeng, Mingyong
• Is Part Of: Journal of functional foods. Volume 72(2020)
• Publication Date: 2020-09
• Subjects: Nonbacterial prostatitis -- Oyster hydrolysates -- Hydrolysate-zinc complex -- Zinc intake -- Amelioration effect; ACP acid phosphatase -- ANOVA analysis of variance -- GSH glutathione -- IL-1β interleukin-1 beta -- MDA malonaldehyde -- OH oyster hydrolysates -- OH-Zn oyster hydrolysate-zinc complex -- PACP prostatic acid phosphatase -- P-control positive control -- PI prostatic index -- PSA prostate-specific antigen -- Sham sham operation -- SOD superoxide dismutase -- TNF-α tumor necrosis factor-alpha -- WBCs white blood cells; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.104066
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: OH-Zn is a nanostructure complex (49.06 ± 0.26 nm) with a prominent signal of zinc. Zinc ions bind to the amino nitrogen atoms and carboxyl oxygen of OH to form OH-Zn. OH-Zn has a high ability of anti-inflammation and inhibition of oxidative stress. OH-Zn has a significant amelioration effect on carrageenan-induced rat prostatitis. Abstract: Nonbacterial prostatitis has been reported to be associated with reduced zinc intake, but the role of zinc remains unclear. Here, oyster hydrolysate-zinc complex (OH-Zn) was prepared to attenuate rat prostatitis. We found using dynamic light scattering and energy-dispersive X-ray analysis that OH-Zn was a nanostructure complex (49.06 ± 0.26 nm) with a prominent signal of zinc. Fourier transform infrared spectroscopy illustrated that OH-Zn was formed via interactions among zinc ions, amino nitrogen atoms and carboxyl oxygen. OH-Zn treatment significantly reduced the prostatic index value, prostatic specific antigen, tumor necrosis factor-alpha, interleukin-1 beta, malonaldehyde, prostatic acid phosphatase, and acid phosphatase in prostatitis rats. OH-Zn increased the levels of superoxide dismutase, glutathione and serum zinc concentration in prostatitis rats relative to the control group. Moreover, histological analyses revealed OH-Zn prevented the carrageen-induced pathological morphology of the prostate. Therefore, OH-Zn might be a preferable paradigm to ameliorate prostatitis as a novel zinc supplement.