Peripheral cytokines are not influenced by the type of surgical approach for non-small cell lung cancer by four weeks postoperatively. (August 2020)

• Record Type: Journal Article
• Authors: Corsini, Erin M.; Wang, Qi; Tran, Hai T.; Mitchell, Kyle G.; Antonoff, Mara B.; Hofstetter, Wayne L.; Mehran, Reza J.; Rice, David C.; Roth, Jack A.; Swisher, Stephen G.; Vaporciyan, Ara A.; Walsh, Garrett L.; Reuben, Alexandre; Vasquez, Mayra E.; Bernatchez, Chantale; Wang, Jing; Cascone, Tina; Zhang, Jianjun; Heymach, John V.; Gibbons, Don L.; Haymaker, Cara L.; Sepesi, Boris
• Is Part Of: Lung cancer. Volume 146(2020)
• Page Start: 303
• Page End: 309
• Publication Date: 2020-08
• Subjects: VATS video-assisted thoracoscopic surgery -- NSCLC non-small cell lung cancer -- CAFs cytokinds, angiogenic, and inflammatory factors -- ICON ImmunogenomiC prOfiling of NSCLC -- IQR interquartile range; Non-small cell lung cancer -- Videoscopic surgery -- Lung cancer surgery -- Cytokines -- Inflammatory molecules; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2020.06.022
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: Peripheral cytokines were studied at postoperatively following lung cancer surgery. Peripheral immune milieus were similar after thoracotomy and videoscopic surgery. All cytokines had returned to baseline levels by 4 weeks postoperatively. Abstract: Objectives: The influence of surgical approach on systemic inflammatory response and the subsequent oncologic impact for non-small cell lung cancer is debated. We aimed to measure the effects of thoracic surgical approach on peripheral cytokine milieu over time. Methods: Patients undergoing primary lung resection without neoadjuvant therapy (2016–2018) were evaluated. A panel of 43 cytokines, angiogenic factors, and inflammatory molecules (CAFs) were evaluated in peripheral blood preoperatively, at 24 -hs and 4-weeks postoperatively. Differences between CAFs in patients undergoing thoracotomy versus video-assisted thoracoscopic surgery (VATS) at all timepoints were assessed using Student's t -test. Results: 76 patients with available peripheral CAF panels met inclusion criteria. Thoracotomy was performed in 53 (70 %) patients while VATS was undertaken in 23 (30 %). Upon examination of known inflammatory CAFs, including IL-1β, IL-6, IL-8, IL-10, IFN-γ, and soluble (s) CD27, no differences were detected at 24 h or 4 weeks postoperatively between surgical groups. Examination of trends over time did not demonstrate any temporal derangements for these CAFs, with return to baseline levels by 4 weeks postoperatively for both groups. Evaluation of soluble (s) checkpoint molecules, including sPD-1, sPD-L1, sTIM-3, and sCTLA-4, did not reveal any differences in the immediate postoperative or long-term recovery period. Conclusions: Peripheral immune profiles following pulmonary resection do not appear to differ between VATS and thoracotomy postoperatively. CAF fluctuations are transient and recover rapidly. These results, at the peripheral cytokine level, suggest that the surgical approach for lung cancer is unlikely to alter the effectiveness of novel immune-modulating systemic therapies, although more studies are needed to validate these findings.