Small Molecules Restore Telomeres in Patient Stem Cells. (August 2020)

• Record Type: Journal Article
• Authors: Brenner, Kirsten Ann; Nandakumar, Jayakrishnan
• Is Part Of: Trends in pharmacological sciences. Volume 41:Number 8(2020)
• Page Start: 506
• Page End: 508
• Publication Date: 2020-08
• Subjects: dyskeratosis congenita -- telomerase -- TERC -- PAPD5 -- PARN -- bone marrow failure; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2020.05.003
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Genetic defects in telomere maintenance result in stem cell exhaustion and a spectrum of telomere biology diseases. Systemic treatments beyond organ transplantation are lacking for these diseases. Nagpal and colleagues identified small molecules that restore telomere maintenance in patient-derived stem cells, offering a promising therapy for telomere biology diseases.