Toxin-Mediated siRNA Delivery. (August 2020)

• Record Type: Journal Article
• Authors: Zhao, Spencer; Karp, Jeffrey M.; Joshi, Nitin
• Is Part Of: Trends in pharmacological sciences. Volume 41:Number 8(2020)
• Page Start: 511
• Page End: 513
• Publication Date: 2020-08
• Subjects: siRNA delivery -- diphtheria toxin -- glioblastoma; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2020.06.006
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : AB toxins with built-in cell targeting and endosomal escape mechanisms are attractive intracellular delivery vehicles. However, their compatibility with nucleic-acid-based therapeutics is not fully explored. Arnold et al. demonstrated the first functional siRNA delivery by diphtheria toxin (DT) in vitro, marking an important step in expanding the utility of AB toxins for nucleic acid delivery.