Issue Information TOC. Issue 3 (18th September 2019)

• Record Type: Journal Article
• Is Part Of: Current protocols in mouse biology. Volume 9:Issue 3(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-09-18
• Subjects: Mice -- Genetics -- Laboratory manuals; Mice; Animals, Laboratory; Research; Mice -- Genetics; Periodicals; Laboratory manuals; 616.027333
• DOI: 10.1002/cpmo.54
• Languages: English
• ISSNs: 2161-2617

Abstract

Abstract : Cover : In Williams et al. (http://doi.org/10.1002/cpmo.64 ) image shows ENU‐mutagenized males are mated to wild‐type females. Each G1 offspring carries a unique set of mutations and therefore will exhibit different phenotypes. To segregate the phenotypes with a mutation or mutations, the G1 male mice are mated to wild‐type females. The G2 offspring are then either intercrossed to each other or mated back to the original G1. The G3 progeny can be phenotyped for both recessive and dominant mutations. Typically, wild‐type females of a different genetic background are used in the breeding scheme to facilitate the genetic mapping of any phenodeviant G3 offspring.