Reduced Complexity in Stroke with Motor Deficits: A Resting-State fMRI Study. (10th May 2020)

• Record Type: Journal Article
• Authors: Liang, Liuke; Hu, Rongliang; Luo, Xuemao; Feng, Bao; Long, Wansheng; Song, Rong
• Is Part Of: Neuroscience. Volume 434(2020)
• Page Start: 35
• Page End: 43
• Publication Date: 2020-05-10
• Subjects: ALFF amplitude of low-frequency fluctuations -- BEN brain entropy -- FMA Fugl-Meyer Assessment -- fMRI functional magnetic resonance imaging -- GRF Gaussian random field -- preCG precentral gyrus -- ReHo regional homogeneity -- SampEn sample entropy -- SFGdor dorsolateral superior frontal gyrus -- SMA supplementary motor area; motor deficits -- stroke -- resting-state fMRI -- brain entropy -- sample entropy -- Complexity; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2020.03.020
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Brain complexity in stroke patients was firstly investigated using brain entropy. Stroke patients showed decreased brain complexity in motor-related regions. No increased brain complexity was found in stroke patients. The decreased brain complexity was positively correlated with the FMA scores. Brain entropy provided significantly different pattern from ReHo and ALFF. Abstract: Recently, alterations of complexity due to brain disorders have been demonstrated using brain entropy (BEN), while the changes of brain complexity in stroke, a common cerebrovascular disease, remain unclear. In this research, resting-state functional magnetic resonance imaging (fMRI) was performed to explore the alterations of brain complexity using BEN in twenty stroke patients with motor deficits and nineteen matched healthy controls. The sample entropy (SampEn) was applied to build the BEN mapping for each participant. Compared with healthy controls, stroke patients exhibited lower BEN values in the contralesional precentral gyrus (preCG), bilateral dorsolateral frontal gyrus (SFGdor) and bilateral supplementary motor area (SMA). Moreover, significantly positive correlations between BEN values and Fugl-Meyer Assessment scores were detected in the ipsilesional SFGdor and ipsilesional SMA. Mutual information independence was observed between BEN and regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), respectively, in the stroke patients. Our findings implied that brain complexity had been impacted after stroke, and also suggested that BEN could be a complementary tool for evaluating the motor impairment after stroke.