A young child with HIV and unsteady gait: A case report. (2020)

• Record Type: Journal Article
• Authors: Yazbeck, Nadine; Youssef, Yolla; Hanna-Wakim, Rima
• Is Part Of: IDCases. Volume 19(2019)
• Publication Date: 2020
• Subjects: ART antiretroviral therapy -- AZT Zidovudine -- 3TC Lamivudine -- PI protease inhibitor -- LPV/r Lopinavir/ritonavir -- CNS central nervous system -- ADH alcohol dehydrogenase -- ALDH aldehyde dehydrogenase -- WHO World Health Organization; HIV -- Lopinavir-ritonavir -- Unsteady gait; Communicable diseases -- Periodicals; Communicable Diseases -- Case Reports; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; 616.9
• DOI: 10.1016/j.idcr.2019.e00643
• Languages: English
• ISSNs: 2214-2509

Abstract

Abstract: Background: We would like to raise awareness about the toxicities related to the added excipients present in the oral solution of Liponavir/ritonavir in particular alcohol and propylene glycol. Case presentation: In this case report, we describe an 18 month-old child with a newly diagnosed HIV infection on antiretroviral therapy (ART). She developed shortly after starting the ART unsteady gait and imbalance. Conclusions: The excipient-excipient interaction in Lopinavir/ritonavir may contribute to major toxicities not only in premature neonates and infants; but also in older children specifically from Asian ethnicity.