Highly Efficient and Convenient Access to Phosphinates via CHCl3‐Assisted Direct Phosphorylation between R2P(O)H and ROH by Phosphonium Salt Catalysis. Issue 20 (8th May 2020)

• Record Type: Journal Article
• Authors: Yu, Xiaojun; Zhang, Song; Jiang, Zhiyu; Zhang, Hong‐Su; Wang, Tianli
• Is Part Of: European journal of organic chemistry. Issue 20(2020)
• Page Start: 3110
• Page End: 3113
• Publication Date: 2020-05-08
• Subjects: Phosphorylation -- Phosphinates -- Homogeneous catalysis -- Reaction mechanisms -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202000385
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A mild, efficient, convenient and scalable method to synthesize phosphinates via direct phosphorylation between R2 P(O)H and ROH was developed. All aromatic substrates completed this transformation with excellent yields (up to 98 %), and preliminary mechanistic studies suggest that a carbene‐involving process from CHCl3 to CH2 Cl2 facilitates the phosphorylation. Abstract : A mild, efficient, convenient, and scalable method to synthesize phosphinates via direct phosphorylation between R2 P(O)H and ROH was developed. Preliminary mechanistic studies suggest that a carbene‐involving process from CHCl3 to CH2 Cl2 facilitates the phosphorylation.