Exploring the controversial role of PI3K signalling in CD4+ regulatory T (T-Reg) cells. (May 2020)

• Record Type: Journal Article
• Authors: Poli, Alessandro; Fiume, Roberta; Mongiorgi, Sara; Zaurito, Antonio; Sheth, Bhavwanti; Vidalle, Magdalena Castellano; Hamid, Shidqiyyah Abdul; Kimber, ScottT.; Campagnoli, Francesca; Ratti, Stefano; Rusciano, Isabella; Faenza, Irene; Manzoli, Lucia; Divecha, Nullin
• Is Part Of: Advances in biological regulation. Volume 76(2020)
• Publication Date: 2020-05
• Subjects: Naive T reg -- PI3K -- FOXOP3 -- Immune system -- Phosphoinositide -- Lipid kinase; Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2020.100722
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: The immune system is a complex network that acts to protect vertebrates from foreign microorganisms and carries out immunosurveillance to combat cancer. In order to avoid hyper-activation of the immune system leading to collateral damage tissues and organs and to prevent self-attack, the network has the intrinsic control mechanisms that negatively regulate immune responses. Central to this negative regulation are regulatory T (T-Reg) cells, which through cytokine secretion and cell interaction limit uncontrolled clonal expansion and functions of activated immune cells. Given that positive or negative manipulation of T-Regs activity could be utilised to therapeutically treat host versus graft rejection or cancer respectively, understanding how signaling pathways impact on T-Regs function should reveal potential targets with which to intervene. The phosphatidylinositol-3-kinase (PI3K) pathway controls a vast array of cellular processes and is critical in T cell activation. Here we focus on phosphoinositide 3-kinases (PI3Ks) and their ability to regulate T-Regs cell differentiation and function.