A fast-responsed fluorescent probe for the selective detection hydrogen sulfide and tert- butoxy radical. Issue 28 (17th July 2020)

• Record Type: Journal Article
• Authors: Dong, Junyang; Hu, Jianfeng; Zhang, Hao
• Is Part Of: Tetrahedron. Volume 76:Issue 28/29(2020)
• Publication Date: 2020-07-17
• Subjects: Carbazole -- Hydrogen sulfide -- Tert-butoxy radical -- Colorimetric probe -- Cell imaging; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2020.131317
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: The fluorescent probe (1) for detecting hydrogen sulfide and tert-butoxy radical in aqueous environment and living cells was first developed. The probe 1 displayed excellent optical properties such as good selectivity, low detection limit (21 nM), quantitative detection (1–10 μM), and very fast response times (<50 s) for monitor of hydrogen sulfide in aqueous environment. Furthermore, the color of the probe 1 solution changed from yellow to colorless when hydrogen sulfide added. More importantly, the probe 1 is successfully used to real-time imaging for hydrogen sulfide and tert-butoxy radical in Hela cells. These merits play a significant role in the process for hydrogen sulfide detection considering the rapid metabolism in organisms. Graphical abstract: A novel fluorescent probe for detecting hydrogen sulfide and tert-butoxy radical in aqueous environment and living cells was developed. Image 1 Highlights: The probe 1 displayed excellent properties for monitor of H2S in aqueous environment. The probe 1 could be used to monitor the redox cycles between H2S and tBuO. by fluorescence spectrum. The probe 1 is successfully used to real-time imaging the variation of H2S and tBuO. in living cells.