Determination of Thirteen Trace and Toxic Elements in Urine Using Inductively Coupled Mass Spectrometry. Issue 1 (20th September 2018)

• Record Type: Journal Article
• Authors: Velez‐Quinones, Maria A.; Xu, Hanna; Vo, Nhu; Gaitens, Joanna M.; McDiarmid, Melissa A.; Lewin‐Smith, Michael R.; Strathmann, Frederick G.
• Editors: Bus, James S.; Costa, Lucio G.; Hodgson, Ernest; Lawrence, David A.; Reed, Donald J.
• Is Part Of: Current protocols in toxicology. Volume 78:Issue 1(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-09-20
• Subjects: ICAP‐Q -- inductively coupled plasma mass spectrometry (ICP‐MS) -- toxic elements -- trace elements -- urine; Toxicology -- Laboratory manuals; Toxicology -- methods; Toxicology; Laboratory Manual; Electronic books; Laboratory manuals; 571.95028
• DOI: 10.1002/cptx.58
• Languages: English
• ISSNs: 1934-9254

Abstract

Abstract: We developed and validated a method for the assessment of thirteen separate trace and toxic elements using Inductively Coupled Plasma‐Mass Spectrometry (ICP‐MS). Included elements were as follows: aluminum, chromium, manganese, iron, cobalt, nickel, copper, zinc, arsenic, molybdenum, cadmium, tungsten, and lead. The measurements of all elements in urine samples were conducted using ICAP‐Q ICP‐MS in a single method. The performance characteristics of the assay were determined according to clinical laboratory standards. The assay was linear in the concentration range of 1.0 to 1000.0 µg/liter for all elements. The method was precise and accurate with limits of quantitation of 1 µg/liter for chromium, manganese, cobalt, nickel, copper, cadmium, tungsten, and lead; 2 µg/liter for iron and arsenic; 5 µg/liter for aluminum; and 50 µg/liter for zinc. This method has successfully been used for the assessment of all thirteen elements included in urine and has been shown to be effective as a simple, precise, and sensitive analytical technique for biological monitoring of urine samples. © 2018 by John Wiley & Sons, Inc.