PredictMed: A logistic regression–based model to predict health conditions in cerebral palsy. (September 2020)

• Record Type: Journal Article
• Authors: Bertoncelli, Carlo M; Altamura, Paola; Vieira, Edgar Ramos; Iyengar, Sundaraja Sitharama; Solla, Federico; Bertoncelli, Domenico
• Is Part Of: Health informatics journal. Volume 26:Number 3(2020)
• Page Start: 2105
• Page End: 2118
• Publication Date: 2020-09
• Subjects: clinical decision-making -- databases -- data mining -- decision-support systems -- machine learning; Medical informatics -- Periodicals; 610.285
• DOI: 10.1177/1460458219898568
• Languages: English
• ISSNs: 1460-4582

Abstract

Logistic regression–based predictive models are widely used in the healthcare field but just recently are used to predict comorbidities in children with cerebral palsy. This article presents a logistic regression approach to predict health conditions in children with cerebral palsy and a few examples from recent research. The model named PredictMed was trained, tested, and validated for predicting the development of scoliosis, intellectual disabilities, autistic features, and in the present study, feeding disorders needing gastrostomy. This was a multinational, cross-sectional descriptive study. Data of 130 children (aged 12–18 years) with cerebral palsy were collected between June 2005 and June 2015. The logistic regression–based model uses an algorithm implemented in R programming language. After splitting the patients in training and testing sets, logistic regressions are performed on every possible subset (tuple) of independent variables. The tuple that shows the best predictive performance in terms of accuracy, sensitivity, and specificity is chosen as a set of independent variables in another logistic regression to calculate the probability to develop the specific health condition (e.g. the need for gastrostomy). The average of accuracy, sensitivity, and specificity score was 90%. Our model represents a novelty in the field of some cerebral palsy–related health outcomes treatment, and it should significantly help doctors' decision-making process regarding patient prognosis.