Peripheral inflammatory markers indicate microstructural damage within periventricular white matter hyperintensities in Alzheimer's disease: A preliminary report. Issue 1 (21st January 2017)

• Record Type: Journal Article
• Authors: Swardfager, Walter; Yu, Di; Ramirez, Joel; Cogo‐Moreira, Hugo; Szilagyi, Gregory; Holmes, Melissa F.; Scott, Christopher J.M.; Scola, Gustavo; Chan, Pak C.; Chen, Jialun; Chan, Parco; Sahlas, Demetrios J.; Herrmann, Nathan; Lanctôt, Krista L.; Andreazza, Ana C.; Pettersen, Jacqueline A.; Black, Sandra E.
• Is Part Of: Alzheimer's & dementia. Volume 7:Issue 1(2017)
• Page Start: 56
• Page End: 60
• Publication Date: 2017-01-21
• Subjects: Small vessel disease -- Cerebrovascular disease -- Diffusion tensor imaging -- Cytokine -- Inflammation -- Microstructure -- White matter disease -- Alzheimer's disease -- Confirmatory factor analysis; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1016/j.dadm.2016.12.011
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: White matter hyperintensities (WMH) presumed to reflect cerebral small vessel disease and increased peripheral inflammatory markers are found commonly in Alzheimer's disease (AD), but their interrelationships remain unclear. Methods: Inflammatory markers were assayed in 54 elderly participants ( n = 16 with AD). Periventricular WMH were delineated from T1, T2/proton density, and fluid‐attenuated magnetic resonance imaging using semiautomated fuzzy lesion extraction and coregistered with maps of fractional anisotropy (FA), a measure of microstructural integrity assessed using diffusion tensor imaging. Results: Mean FA within periventricular WMH was associated with an inflammatory factor consisting of interleukin (IL)‐1β, tumor necrosis factor, IL‐10, IL‐21, and IL‐23 in patients with AD (ρ = −0.703, P = .002) but not in healthy elderly (ρ = 0.217, P = .190). Inflammation was associated with greater FA in deep WMH in healthy elderly (ρ = 0.425, P = .008) but not in patients with AD (ρ = 0.174, P = .520). Discussion: Peripheral inflammatory markers may be differentially related to microstructural characteristics within the white matter affected by cerebral small vessel disease in elders with and without AD.