Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry. Issue 1 (30th August 2017)

• Record Type: Journal Article
• Authors: Tward, Daniel J.; Sicat, Chelsea S.; Brown, Timothy; Bakker, Arnold; Gallagher, Michela; Albert, Marilyn; Miller, Michael
• Is Part Of: Alzheimer's & dementia. Volume 9:Issue 1(2017)
• Page Start: 41
• Page End: 50
• Publication Date: 2017-08-30
• Subjects: Entorhinal cortex -- Mild cognitive impairment -- Braak staging -- Diffeomorphometry -- Shape analysis -- Longitudinal analysis; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1016/j.dadm.2017.07.005
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease. Methods: Here, we study this region in subjects with mild cognitive impairment ( n = 36) and in control subjects ( n = 16). The cortical areas are manually segmented, and local volume and shape changes are quantified using diffeomorphometry, including a novel mapping procedure that reduces variability in anatomic definitions over time. Results: We find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing. Discussion: This demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment.