Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies. Issue 1 (16th April 2019)

• Record Type: Journal Article
• Authors: Perani, Daniela; Iaccarino, Leonardo; Jacobs, Andreas H.; Lammertsma, Adriaan A.; Nordberg, Agneta; Windhorst, Albert D.; Gerhard, Alexander; Winkeler, Alexandra; Jacobs, Andreas H.; Gee, Anthony; Kuhnast, Bertrand; Halldin, Christer; Perani, Daniela; Brooks, David; Rodriguez‐Vieitez, Elena; Turkheimer, Federico E.; López‐Picón, Francisco; Knudsen, Gitte M.; Vercouillie, Johnny; Rinne, Juha O.; Herholz, Karl; Van Laere, Koen; Varrone, Andrea; Santiago‐Ribeiro, Marie Joao; Herth, Matthias M.; Carroll, Michael A.; Chalon, Sylvie; Bottlaender, Michel; Hansson, Oskar; Edison, Paul; Hinz, Rainer; Boellaard, Ronald; Moresco, Rosa Maria; Pappata, Sabina;
• Is Part Of: Alzheimer's & dementia. Volume 11:Issue 1(2019)
• Page Start: 327
• Page End: 332
• Publication Date: 2019-04-16
• Subjects: PET molecular imaging -- Radiotracers -- Protheinopathies -- Amyloid -- Tau -- Neuroinflammation; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1016/j.dadm.2019.02.004
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: A rapid transition from a clinical‐based classification to a pathology‐based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi‐tracer molecular Brain Imaging, funded by the EU Joint Program ‐ Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration, " aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia. Methods: We consider current and future implications of adopting a pathology‐based framework for the use and development of positron emission tomography techniques. Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias. Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.