Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study. Issue 1 (31st October 2016)

• Record Type: Journal Article
• Authors: Li, Danni; Misialek, Jeffrey R.; Boerwinkle, Eric; Gottesman, Rebecca F.; Sharrett, A. Richey; Mosley, Thomas H.; Coresh, Josef; Wruck, Lisa M.; Knopman, David S.; Alonso, Alvaro
• Is Part Of: Alzheimer's & dementia. Volume 6:Issue 1(2017)
• Page Start: 1
• Page End: 10
• Publication Date: 2016-10-31
• Subjects: Phospholipids -- Plasma -- Mild cognitive impairment -- MCI -- Dementia -- Metabolomics -- Metabolites -- ARIC‐NCS -- ARIC -- Alzheimer's disease -- AD; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1016/j.dadm.2016.09.003
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: The objective of this study was to investigate whether 10 phospholipids/metabolites previously identified as prospectively predictive of mild cognitive impairment (MCI) or dementia in whites would also be predictive in a mostly African‐American cohort. Methods: We repeatedly measured 188 phospholipids/metabolites in plasma samples of 221 participants of the Atherosclerosis Risk in Communities study, 97% African American, who were followed between 2004–2006 and 2011–2013. Results: After a mean follow‐up of 7.3 years, 77 were classified as having MCI and 18 as having dementia. Our study failed to replicate previous findings in this mostly African American cohort, in that the 10 phospholipids/metabolites only achieved a C statistic/AUC of 0.609 in predicting development of MCI or dementia (compared to 0.96) and 0.607 in distinguishing normal from MCI or dementia at the follow‐up visit. Conclusion: A panel of 10 phospholipids/metabolites previously associated with incident dementia was not predictive of MCI or dementia in an independent cohort.