UNIT 9.23 Management of Incidental Findings in Clinical Genomic Sequencing. (April 2013)

• Record Type: Journal Article
• Authors: Krier, Joel B.; Green, Robert C.
• Is Part Of: Current protocols in human genetics. Volume 77(2013)
• Page Start: 9.23.1
• Page End: 9.23.13
• Publication Date: 2013-04
• Subjects: incidental findings -- genomics -- sequencing -- whole genome -- exome; Human genetics -- Laboratory manuals; Genetic Techniques; Human genetics; Laboratory manuals; 599.935028
• DOI: 10.1002/0471142905.hg0923s77
• Languages: English
• ISSNs: 1934-8258

Abstract

Abstract: Genomic sequencing is becoming accurate, fast, and inexpensive, and is rapidly being incorporated into clinical practice. Incidental findings, which result in large numbers from genomic sequencing, are a potential barrier to the utility of this new technology due to their high prevalence and the lack of evidence or guidelines available to guide their clinical interpretation. This unit reviews the definition, classification, and management of incidental findings from genomic sequencing. The unit focuses on the clinical aspects of handling incidental findings, with an emphasis on the key role of clinical context in defining incidental findings and determining their clinical relevance and utility. Curr. Protoc. Hum. Genet. 77:9.23.1‐9.23.13. © 2013 by John Wiley & Sons, Inc.