The effect of pelvic radiation alone on lymphocyte subgroups. (July 2020)

• Record Type: Journal Article
• Authors: Swanson, Gregory P.; Jhavar, Sameer G.; Hammonds, Kendall
• Is Part Of: Clinical and translational radiation oncology. Volume 23(2020)
• Page Start: 100
• Page End: 102
• Publication Date: 2020-07
• Subjects: Lymphocytes -- Lymphocyte subsets -- Radiation effects; Cancer -- Radiotherapy -- Periodicals; Oncology -- Periodicals; Cancer -- Radiotherapy; Oncology; Radiation Oncology; Neoplasms -- radiotherapy; Translational Medical Research; Periodicals; Electronic journals; Periodicals; 616.9940642
• DOI: 10.1016/j.ctro.2020.05.010
• Languages: English
• ISSNs: 2405-6308

Abstract

Highlights: Radiation therapy alone has dramatic effects on lymphocyte subgroups. CD4+, CD8+ and CD56+ counts drop by >70%, CD 19+ by >90%. Three months post exposure, no subgroup has returned to baseline levels. All subgroups except CD 56+ (including CD19+) recovered modestly to about 40% of pre-treatment levels. CD56+ were more resistant and recovered to 64% of pretreatment levels. CD56+ cells recover more fully (to >60% of pretreatment levels). Abstract: There is a lack of information on the radiosensitivity of lymphocyte subgroups to radiation alone. CD4+ and CD8+ lymphocytes respond similarly. CD 19+ dropped most precipitously, but recovered to levels similar to the other subgroups by 3 months. NK cells decline more modestly and recover more fully by 3 months.