The Quality of Reporting Raises Questions on the Experimental Validity of Animal Studies Conducted in India and Sri Lanka: Preliminary Analysis of a Systematic Survey. Issue 2 (March 2020)

• Record Type: Journal Article
• Authors: Singh, Vijay Pal; Jain, Ayushi; Gupta, Shubhra; Vijayakumar, Manudharshy; Pratap, Kunal; Maheshwari, Deepanshu; Thoradeniya, Tharanga
• Is Part Of: ATLA. Volume 48:Issue 2(2020)
• Page Start: 85
• Page End: 91
• Publication Date: 2020-03
• Subjects: animal models -- ARRIVE guidelines -- blinding -- randomisation -- sample size; Laboratory animals -- Periodicals; 616.0273
• DOI: 10.1177/0261192920923105
• Languages: English
• ISSNs: 0261-1929

Abstract

The quality of animal experiments in terms of appropriate reporting is a concern, particularly with regard to their validity and the recording of the measures taken to reduce various types of bias. A systematic survey of 1371 and 236 publications from India and Sri Lanka, respectively, which were published between 1905 and 2017 and indexed in NCBI-PubMed, Cinhal, MEDLINE and Scopus, was carried out. The level of detail in the descriptions of animals used and the measures taken to reduce bias were analysed in each article. Selected parameters from the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines, such as age, weight, sex, sample size calculation, blinding and randomisation were considered. The findings revealed poor reporting standards in animal experiments carried out in India and Sri Lanka, confirming the limited impact of the ARRIVE guidelines. These findings emphasise the urgent need for improvements in the peer review process, both prior to a study being set up and in the post-study reporting phase, and for more stringent adherence to the ARRIVE guidelines in the reporting of animal experiments.