Granulomatous interstitial nephritis in the setting of disseminated Mycobacterium simiae: a rare presentation of immune reconstitution inflammatory syndrome. (August 2020)

• Record Type: Journal Article
• Authors: Salas, Natalie Mariam; Byrd, Thomas F
• Is Part Of: International journal of STD & AIDS. Volume 31:Number 9(2020)
• Page Start: 911
• Page End: 913
• Publication Date: 2020-08
• Subjects: Granulomatous interstitial nephritis -- Mycobacterium simiae -- non-tuberculous mycobacteria -- immune reconstitution inflammatory syndrome; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462420926881
• Languages: English
• ISSNs: 0956-4624

Abstract

Disseminated Mycobacterium simiae is a rare opportunistic infection reported most commonly in advanced human immunodeficiency virus (HIV) infection. Treatment can be further complicated by the occurrence of severe immune reconstitution inflammatory syndrome (IRIS). We present the first case of disseminated multi-drug-resistant M. simiae in the setting of advanced HIV, complicated by IRIS in the form of granulomatous interstitial nephritis causing acute renal failure. This case highlights the importance of recognizing rare complications of IRIS, as delays in therapy can be life threatening.