Mucoepidermoid Carcinoma of the Breast With MAML2 Rearrangement: A Case Report and Literature Review. (October 2020)

• Record Type: Journal Article
• Authors: Yan, Mingfei; Gilmore, Hannah; Harbhajanka, Aparna
• Is Part Of: International journal of surgical pathology. Volume 28:Number 7(2020)
• Page Start: 787
• Page End: 792
• Publication Date: 2020-10
• Subjects: mucoepidermoid -- carcinoma -- breast -- MAML2 -- review; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896920916779
• Languages: English
• ISSNs: 1066-8969

Abstract

Mucoepidermoid carcinoma is one of the most common malignancies in salivary glands. In comparison, breast mucoepidermoid carcinoma is a very rare entity, with limited reports and understanding of its clinical behaviors to date. In this article, we report a case of low-grade breast mucoepidermoid carcinoma of a 60-year-old female patient. Histologic and immunohistochemical patterns were demonstrated. Fluorescence in situ hybridization test was also conducted to identify MAML2 rearrangement in this case, indicating a similar molecular abnormality as mucoepidermoid carcinoma in the salivary gland. Five-year follow-up of the patient showed no local recurrence or distant metastasis of the carcinoma, indicating the indolent behavior of low-grade breast mucoepidermoid carcinoma. Besides, a 40-year literature review from 1979 to 2019 was also performed to better characterize the prognosis and molecular abnormalities of the lesion.